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ea0073oc12.1 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Prevention of glucocorticoid-induced adipose dysfunction through selective activation of β3-adrenergic signaling in mice

Gado Manuel , Heinrich Annett , Wiedersich Denise , Noll Monique , Bornstein Stefan R. , Rauner Martina , Hofbauer Lorenz C. , Henneicke Holger

Despite their therapeutic effectiveness, glucocorticoids (GC) clinical usage is frequently limited due to the deleterious metabolic effects. GC-induced obesity arises from excessive fat accumulation in white adipose tissue (WAT) as well as suppressed thermogenic capacity in brown adipose tissue (BAT). Since the sympathetic nervous system (SNS) plays a fundamental role in adipose tissue biology, we examined the interaction between GCs and SNS signaling in the adipose orga...

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Prevention of glucocorticoid-induced adipose dysfunction through selective activation of β3-adrenergic signaling in mice

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